Title |
Tryptophan degradation in women with breast cancer: a pilot study
|
---|---|
Published in |
BMC Research Notes, May 2011
|
DOI | 10.1186/1756-0500-4-156 |
Pubmed ID | |
Authors |
Debra E Lyon, Jeanne M Walter, Angela R Starkweather, Christine M Schubert, Nancy L McCain |
Abstract |
Altered tryptophan metabolism and indoleamine 2,3-dioxygenase activity are linked to cancer development and progression. In addition, these biological factors have been associated with the development and severity of neuropsychiatric syndromes, including major depressive disorder. However, this biological mechanism associated with both poor disease outcomes and adverse neuropsychiatric symptoms has received little attention in women with breast cancer. Therefore, a pilot study was undertaken to compare levels of tryptophan and other proteins involved in tryptophan degradation in women with breast cancer to women without cancer, and secondarily, to examine levels in women with breast caner over the course of chemotherapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Czechia | 1 | 1% |
Unknown | 72 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 22% |
Researcher | 12 | 16% |
Student > Master | 7 | 10% |
Student > Bachelor | 7 | 10% |
Student > Postgraduate | 5 | 7% |
Other | 12 | 16% |
Unknown | 14 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 18% |
Agricultural and Biological Sciences | 10 | 14% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Chemistry | 5 | 7% |
Psychology | 4 | 5% |
Other | 17 | 23% |
Unknown | 15 | 21% |