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CSF-1R as an inhibitor of apoptosis and promoter of proliferation, migration and invasion of canine mammary cancer cells

Overview of attention for article published in BMC Veterinary Research, April 2013
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  • Good Attention Score compared to outputs of the same age and source (74th percentile)

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Title
CSF-1R as an inhibitor of apoptosis and promoter of proliferation, migration and invasion of canine mammary cancer cells
Published in
BMC Veterinary Research, April 2013
DOI 10.1186/1746-6148-9-65
Pubmed ID
Authors

Magdalena Król, Kinga Majchrzak, Joanna Mucha, Agata Homa, Małgorzata Bulkowska, Arleta Jakubowska, Malwina Karwicka, Karol M Pawłowski, Tomasz Motyl

Abstract

Tumor-associated macrophages (TAMs) have high impact on the cancer development because they can facilitate matrix invasion, angiogenesis, and tumor cell motility. It gives cancer cells the capacity to invade normal tissues and metastasize. The signaling of colony-stimulating factor-1 receptor (CSF-1R) which is an important regulator of proliferation and differentiation of monocytes and macrophages regulates most of the tissue macrophages. However, CSF-1R is expressed also in breast epithelial tissue during some physiological stages i.g.: pregnancy and lactation. Its expression has been also detected in various cancers. Our previous study has showed the expression of CSF-1R in all examined canine mammary tumors. Moreover, it strongly correlated with grade of malignancy and ability to metastasis. This study was therefore designed to characterize the role of CSF-1R in canine mammary cancer cells proliferation, apoptosis, migration, and invasion. As far as we know, the study presented hereby is a pioneering experiment in this field of veterinary medicine.

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X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Brazil 1 2%
Unknown 47 96%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 10 20%
Student > Bachelor 7 14%
Student > Master 6 12%
Researcher 5 10%
Student > Doctoral Student 4 8%
Other 13 27%
Unknown 4 8%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 18 37%
Agricultural and Biological Sciences 9 18%
Medicine and Dentistry 8 16%
Biochemistry, Genetics and Molecular Biology 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 2 4%
Unknown 6 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2013.
All research outputs
#12,813,078
of 22,703,044 outputs
Outputs from BMC Veterinary Research
#806
of 3,037 outputs
Outputs of similar age
#101,882
of 199,926 outputs
Outputs of similar age from BMC Veterinary Research
#12
of 47 outputs
Altmetric has tracked 22,703,044 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,037 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,926 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.