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Mendeley readers
| Title |
Signaling and regulation of G protein-coupled receptors in airway smooth muscle
|
|---|---|
| Published in |
Respiratory Research, March 2003
|
| DOI | 10.1186/1465-9921-4-2 |
| Pubmed ID | |
| Authors |
Charlotte K Billington, Raymond B Penn |
| Abstract |
Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state. |
Mendeley readers
The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 1% |
| United States | 3 | 1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 216 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 50 | 22% |
| Student > Ph. D. Student | 49 | 22% |
| Researcher | 25 | 11% |
| Student > Master | 22 | 10% |
| Student > Postgraduate | 8 | 4% |
| Other | 19 | 9% |
| Unknown | 50 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 23% |
| Biochemistry, Genetics and Molecular Biology | 38 | 17% |
| Medicine and Dentistry | 34 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 22 | 10% |
| Engineering | 6 | 3% |
| Other | 18 | 8% |
| Unknown | 54 | 24% |