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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy
|
|---|---|
| Published in |
Breast Cancer Research, March 2013
|
| DOI | 10.1186/bcr3401 |
| Pubmed ID | |
| Authors |
Mun Hui, Aurélie Cazet, Radhika Nair, D Neil Watkins, Sandra A O'Toole, Alexander Swarbrick |
| Abstract |
Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. In order to make an impact on survival in this type of aggressive breast cancer, new targeted therapeutic agents are urgently needed. Aberrant activation of the Hedgehog (Hh) signalling pathway has been unambiguously tied to cancer development and progression in a variety of solid malignancies, and the recent approval of vismodegib, an orally bioavailable small-molecule inhibitor of Smoothened, validates Hh signalling as a valuable therapeutic target. A number of recent publications have highlighted a role for Hh signalling in breast cancer models and clinical specimens. Interestingly, Hh ligand overexpression is associated with the BLBC phenotype and a poor outcome in terms of metastasis and breast cancer-related death. In this review, we provide a comprehensive overview of the canonical Hh signalling pathway in mammals, highlight its roles in mammary gland development and breast carcinogenesis and discuss its potential therapeutic value in BLBC. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Kenya | 1 | <1% |
| India | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Nigeria | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 111 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 24% |
| Student > Ph. D. Student | 25 | 21% |
| Student > Bachelor | 17 | 14% |
| Student > Master | 12 | 10% |
| Other | 6 | 5% |
| Other | 12 | 10% |
| Unknown | 18 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 29% |
| Medicine and Dentistry | 26 | 22% |
| Biochemistry, Genetics and Molecular Biology | 23 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Computer Science | 2 | 2% |
| Other | 5 | 4% |
| Unknown | 21 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2016.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Breast Cancer Research
#1,535
of 2,053 outputs
Outputs of similar age
#135,111
of 210,250 outputs
Outputs of similar age from Breast Cancer Research
#23
of 29 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,250 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.