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Mendeley readers
Attention Score in Context
| Title |
Mobile elements in the human genome: implications for disease
|
|---|---|
| Published in |
Genome Medicine, February 2012
|
| DOI | 10.1186/gm311 |
| Pubmed ID | |
| Authors |
Szilvia Solyom, Haig H Kazazian |
| Abstract |
Perhaps as much as two-thirds of the mammalian genome is composed of mobile genetic elements ('jumping genes'), a fraction of which is still active or can be reactivated. By their sheer number and mobility, retrotransposons, DNA transposons and endogenous retroviruses have shaped our genotype and phenotype both on an evolutionary scale and on an individual level. Notably, at least the non-long terminal repeat retrotransposons are still able to cause disease by insertional mutagenesis, recombination, providing enzymatic activities for other mobile DNA, and perhaps by transcriptional overactivation and epigenetic effects. Currently, there are nearly 100 examples of known retroelement insertions that cause disease. In this review, we highlight those genome-scale technologies that have expanded our knowledge of the diseases that these mobile elements can elicit, and we discuss the potential impact of these findings for medicine. It is now likely that at least some types of cancer and neurological disorders arise as a result of retrotransposon mutagenesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Portugal | 1 | <1% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Egypt | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 162 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 17% |
| Student > Bachelor | 27 | 16% |
| Researcher | 27 | 16% |
| Student > Master | 26 | 15% |
| Student > Doctoral Student | 10 | 6% |
| Other | 31 | 18% |
| Unknown | 19 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 63 | 37% |
| Biochemistry, Genetics and Molecular Biology | 52 | 31% |
| Medicine and Dentistry | 13 | 8% |
| Computer Science | 4 | 2% |
| Neuroscience | 3 | 2% |
| Other | 11 | 7% |
| Unknown | 23 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2023.
All research outputs
#2,153,389
of 25,016,456 outputs
Outputs from Genome Medicine
#480
of 1,544 outputs
Outputs of similar age
#11,997
of 160,713 outputs
Outputs of similar age from Genome Medicine
#2
of 16 outputs
Altmetric has tracked 25,016,456 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,544 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.1. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,713 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.