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DDIG-in: discriminating between disease-associated and neutral non-frameshifting micro-indels

Overview of attention for article published in Genome Biology, March 2013
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Title
DDIG-in: discriminating between disease-associated and neutral non-frameshifting micro-indels
Published in
Genome Biology, March 2013
DOI 10.1186/gb-2013-14-3-r23
Pubmed ID
Authors

Huiying Zhao, Yuedong Yang, Hai Lin, Xinjun Zhang, Matthew Mort, David N Cooper, Yunlong Liu, Yaoqi Zhou

Abstract

Micro-indels (insertions or deletions shorter than 21 bps) constitute the second most frequent class of human gene mutation after single nucleotide variants. Despite the relative abundance of non-frameshifting indels, their damaging effect on protein structure and function has gone largely unstudied. We have developed a support vector machine-based method named DDIG-in (Detecting disease-causing genetic variations due to indels) to prioritize non-frameshifting indels by comparing disease-associated mutations with putatively neutral mutations from the 1,000 Genomes Project. The final model gives good discrimination for indels and is robust against annotation errors. A webserver implementing DDIG-in is available at http://sparks-lab.org/ddig.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hong Kong 1 2%
United States 1 2%
Germany 1 2%
Unknown 49 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 21%
Researcher 10 19%
Student > Bachelor 5 10%
Student > Master 5 10%
Professor 3 6%
Other 10 19%
Unknown 8 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 31%
Biochemistry, Genetics and Molecular Biology 14 27%
Computer Science 7 13%
Medicine and Dentistry 1 2%
Chemistry 1 2%
Other 1 2%
Unknown 12 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2013.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Genome Biology
#4,269
of 4,467 outputs
Outputs of similar age
#160,973
of 208,880 outputs
Outputs of similar age from Genome Biology
#45
of 45 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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