Title |
Airway epithelial cells initiate the allergen response through transglutaminase 2 by inducing IL-33 expression and a subsequent Th2 response
|
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Published in |
Respiratory Research, March 2013
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DOI | 10.1186/1465-9921-14-35 |
Pubmed ID | |
Authors |
Keunhee Oh, Myung Won Seo, Ga Young Lee, Ok-Jin Byoun, Hye-Ryun Kang, Sang-Heon Cho, Dong-Sup Lee |
Abstract |
Transglutaminase 2 (TG2) is a post-translational protein-modifying enzyme that catalyzes the transamidation reaction, producing crosslinked or polyaminated proteins. Increased TG2 expression and activity have been reported in various inflammatory conditions, such as rheumatoid arthritis, inflammation-associated pulmonary fibrosis, and autoimmune encephalitis. In particular, TG2 from epithelial cells is important during the initial inflammatory response in the lung. In this study, we evaluated the role of TG2 in the pathogenesis of allergic asthma, particularly whether TG2 affects initial activation signaling leading to Th2 differentiation against antigens. |
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