Title |
Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology
|
---|---|
Published in |
Journal of Translational Medicine, April 2013
|
DOI | 10.1186/1479-5876-11-93 |
Pubmed ID | |
Authors |
Elizabeth Ann Stringer, Katharine Susanne Baker, Ian R Carroll, Jose G Montoya, Lily Chu, Holden T Maecker, Jarred W Younger |
Abstract |
Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by persistent fatigue that is not alleviated by rest. The lack of a clearly identified underlying mechanism has hindered the development of effective treatments. Studies have demonstrated elevated levels of inflammatory factors in patients with CFS, but findings are contradictory across studies and no biomarkers have been consistently supported. Single time-point approaches potentially overlook important features of CFS, such as fluctuations in fatigue severity. We have observed that individuals with CFS demonstrate significant day-to-day variability in their fatigue severity. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 19 | 23% |
United Kingdom | 15 | 18% |
Netherlands | 6 | 7% |
Germany | 4 | 5% |
Spain | 1 | 1% |
Switzerland | 1 | 1% |
Japan | 1 | 1% |
Australia | 1 | 1% |
Belgium | 1 | 1% |
Other | 3 | 4% |
Unknown | 32 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 70 | 83% |
Scientists | 5 | 6% |
Practitioners (doctors, other healthcare professionals) | 5 | 6% |
Science communicators (journalists, bloggers, editors) | 4 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Norway | 1 | <1% |
Australia | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 119 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 18% |
Other | 17 | 14% |
Student > Ph. D. Student | 17 | 14% |
Student > Master | 16 | 13% |
Student > Bachelor | 10 | 8% |
Other | 22 | 18% |
Unknown | 20 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 40 | 32% |
Agricultural and Biological Sciences | 14 | 11% |
Biochemistry, Genetics and Molecular Biology | 10 | 8% |
Psychology | 10 | 8% |
Nursing and Health Professions | 6 | 5% |
Other | 18 | 15% |
Unknown | 26 | 21% |