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Histological evaluation of symptomatic ossification of the anterior longitudinal ligament treated with etidronate disodium: a case report

Overview of attention for article published in Journal of Medical Case Reports, November 2016
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Title
Histological evaluation of symptomatic ossification of the anterior longitudinal ligament treated with etidronate disodium: a case report
Published in
Journal of Medical Case Reports, November 2016
DOI 10.1186/s13256-016-1100-7
Pubmed ID
Authors

Yusuke Sugimura, Naohisa Miyakoshi, Yuji Kasukawa, Michio Hongo, Yoichi Shimada

Abstract

Here we report the first autopsied case involving pathological examination after two resections of symptomatic ossification of the anterior longitudinal ligament with anterior osteophytes and etidronate treatment with more than 8 years of follow-up. A 51-year-old Japanese man complained of severe dysphagia due to esophageal compression by ossification of his anterior longitudinal ligament with anterior cervical osteophytes. Although surgical removal of the anterior cervical osteophytes was performed following etidronate treatment (800 mg/day for 6 months), dysphagia occurred secondary to recurrent ossification of his anterior longitudinal ligament with anterior osteophytes 7 years after the initial resection. A second resection of the anterior cervical osteophytes was performed, and cyclic administration of etidronate disodium (1000 mg/day, 3-month administration and 3-month cessation) did not result in re-outgrowth of ossification of his anterior longitudinal ligament with anterior osteophytes. At 1 year and 6 months after the second surgery, he suddenly died. The pathological findings associated with the ossification of his anterior longitudinal ligament during etidronate therapy showed no recurrence of ossification of the anterior longitudinal ligament with anterior osteophytes. A recurrence of ossification of the anterior longitudinal ligament with anterior osteophytes formation, which caused dysphagia, was not observed with the cyclic administration of etidronate disodium at a dose of 1000 mg/day every 3 months for a period of 1 year and 5 months in the present case.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 31%
Other 3 23%
Student > Doctoral Student 1 8%
Professor 1 8%
Student > Bachelor 1 8%
Other 2 15%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 5 38%
Engineering 2 15%
Psychology 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Neuroscience 1 8%
Other 1 8%
Unknown 2 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2016.
All research outputs
#18,482,034
of 22,901,818 outputs
Outputs from Journal of Medical Case Reports
#2,267
of 3,934 outputs
Outputs of similar age
#236,930
of 312,770 outputs
Outputs of similar age from Journal of Medical Case Reports
#52
of 108 outputs
Altmetric has tracked 22,901,818 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,934 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.