Title |
Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review
|
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Published in |
Respiratory Research, November 2016
|
DOI | 10.1186/s12931-016-0471-z |
Pubmed ID | |
Authors |
Elisabetta Zinellu, Angelo Zinellu, Alessandro Giuseppe Fois, Ciriaco Carru, Pietro Pirina |
Abstract |
Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airflow limitation associated with an abnormal inflammatory response of the lungs to noxious particles and gases, caused primarily by cigarette smoking. Increased oxidative burden plays an important role in the pathogenesis of COPD. There is a delicate balance between the toxicity of oxidants and the protective function of the intracellular and extracellular antioxidant defense systems, which is critically important for the maintenance of normal pulmonary functions. Several biomarkers of oxidative stress are available and have been evaluated in COPD. In this review, we summarize the main literature findings about circulating oxidative stress biomarkers, grouped according to their method of detection, measured in COPD subjects. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 60% |
United States | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 1% |
Unknown | 98 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 19% |
Researcher | 10 | 10% |
Student > Ph. D. Student | 9 | 9% |
Student > Postgraduate | 6 | 6% |
Student > Doctoral Student | 4 | 4% |
Other | 13 | 13% |
Unknown | 38 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 13% |
Biochemistry, Genetics and Molecular Biology | 11 | 11% |
Nursing and Health Professions | 10 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Agricultural and Biological Sciences | 4 | 4% |
Other | 16 | 16% |
Unknown | 40 | 40% |