Title |
Early differentiation patterning of mouse embryonic stem cells in response to variations in alginate substrate stiffness
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Published in |
Journal of Biological Engineering, April 2013
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DOI | 10.1186/1754-1611-7-9 |
Pubmed ID | |
Authors |
Joseph Candiello, Satish S Singh, Keith Task, Prashant N Kumta, Ipsita Banerjee |
Abstract |
Embryonic stem cells (ESCs) have been implicated to have tremendous impact in regenerative therapeutics of various diseases, including Type 1 Diabetes. Upon generation of functionally mature ESC derived islet-like cells, they need to be implanted into diabetic patients to restore the loss of islet activity. Encapsulation in alginate microcapsules is a promising route of implantation, which can protect the cells from the recipient's immune system. While there has been a significant investigation into islet encapsulation over the past decade, the feasibility of encapsulation and differentiation of ESCs has been less explored. Research over the past few years has identified the cellular mechanical microenvironment to play a central role in phenotype commitment of stem cells. Therefore it will be important to design the encapsulation material to be supportive to cellular functionality and maturation. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Germany | 1 | 1% |
Unknown | 70 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 23% |
Researcher | 13 | 18% |
Student > Bachelor | 13 | 18% |
Student > Master | 5 | 7% |
Student > Doctoral Student | 2 | 3% |
Other | 6 | 8% |
Unknown | 17 | 23% |
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Biochemistry, Genetics and Molecular Biology | 9 | 12% |
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Chemistry | 4 | 5% |
Other | 8 | 11% |
Unknown | 18 | 25% |