Title |
Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking
|
---|---|
Published in |
Malaria Journal, April 2013
|
DOI | 10.1186/1475-2875-12-118 |
Pubmed ID | |
Authors |
Gisela Henriques, Axel Martinelli, Louise Rodrigues, Katarzyna Modrzynska, Richard Fawcett, Douglas R Houston, Sofia T Borges, Umberto d’Alessandro, Halidou Tinto, Corine Karema, Paul Hunt, Pedro Cravo |
Abstract |
The control of malaria, caused by Plasmodium falciparum, is hampered by the relentless evolution of drug resistance. Because artemisinin derivatives are now used in the most effective anti-malarial therapy, resistance to artemisinin would be catastrophic. Indeed, studies suggest that artemisinin resistance has already appeared in natural infections. Understanding the mechanisms of resistance would help to prolong the effective lifetime of these drugs. Genetic markers of resistance are therefore required urgently. Previously, a mutation in a de-ubiquitinating enzyme was shown to confer artemisinin resistance in the rodent malaria parasite Plasmodium chabaudi. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 5 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 3% |
Brazil | 1 | 1% |
Switzerland | 1 | 1% |
Belgium | 1 | 1% |
Rwanda | 1 | 1% |
Unknown | 89 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 19% |
Student > Master | 15 | 16% |
Student > Bachelor | 14 | 15% |
Researcher | 12 | 13% |
Student > Doctoral Student | 7 | 7% |
Other | 17 | 18% |
Unknown | 13 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 29% |
Biochemistry, Genetics and Molecular Biology | 23 | 24% |
Medicine and Dentistry | 15 | 16% |
Chemistry | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 6 | 6% |
Unknown | 15 | 16% |