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Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

Overview of attention for article published in Malaria Journal, April 2013
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Citations

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96 Mendeley
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Title
Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking
Published in
Malaria Journal, April 2013
DOI 10.1186/1475-2875-12-118
Pubmed ID
Authors

Gisela Henriques, Axel Martinelli, Louise Rodrigues, Katarzyna Modrzynska, Richard Fawcett, Douglas R Houston, Sofia T Borges, Umberto d’Alessandro, Halidou Tinto, Corine Karema, Paul Hunt, Pedro Cravo

Abstract

The control of malaria, caused by Plasmodium falciparum, is hampered by the relentless evolution of drug resistance. Because artemisinin derivatives are now used in the most effective anti-malarial therapy, resistance to artemisinin would be catastrophic. Indeed, studies suggest that artemisinin resistance has already appeared in natural infections. Understanding the mechanisms of resistance would help to prolong the effective lifetime of these drugs. Genetic markers of resistance are therefore required urgently. Previously, a mutation in a de-ubiquitinating enzyme was shown to confer artemisinin resistance in the rodent malaria parasite Plasmodium chabaudi.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
Brazil 1 1%
Switzerland 1 1%
Belgium 1 1%
Rwanda 1 1%
Unknown 89 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 19%
Student > Master 15 16%
Student > Bachelor 14 15%
Researcher 12 13%
Student > Doctoral Student 7 7%
Other 17 18%
Unknown 13 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 29%
Biochemistry, Genetics and Molecular Biology 23 24%
Medicine and Dentistry 15 16%
Chemistry 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 6 6%
Unknown 15 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2021.
All research outputs
#13,382,001
of 22,705,019 outputs
Outputs from Malaria Journal
#3,502
of 5,545 outputs
Outputs of similar age
#106,975
of 199,925 outputs
Outputs of similar age from Malaria Journal
#43
of 76 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,545 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,925 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.