Title |
Engineering of papaya mosaic virus (PapMV) nanoparticles with a CTL epitope derived from influenza NP
|
---|---|
Published in |
Journal of Nanobiotechnology, April 2013
|
DOI | 10.1186/1477-3155-11-10 |
Pubmed ID | |
Authors |
Cindy Babin, Nathalie Majeau, Denis Leclerc |
Abstract |
The ever-present threat of infectious disease, e.g. influenza pandemics, and the increasing need for new and effective treatments in immunotherapy are the driving forces that motivate research into new and innovative vaccine platforms. Ideally, such platforms should trigger an efficient CTL response, be safe, and easy to manufacture. We recently developed a novel nanoparticle adjuvant comprised of papaya mosaic virus (PapMV) coat protein (CP) assembled around an RNA. The PapMV nanoparticle is an efficient vaccine platform in which the peptide antigen is fused to the C-terminus of the PapMV CP, leading to nanoparticles presenting surface-exposed epitope. The fusion stabilizes the epitope and improves its immunogenicity. We found recently that C-terminal fusions are not always efficient, depending on the nature of the peptide fused to the platform. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 5% |
Unknown | 39 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 24% |
Student > Master | 9 | 22% |
Researcher | 7 | 17% |
Student > Bachelor | 4 | 10% |
Student > Doctoral Student | 2 | 5% |
Other | 5 | 12% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 41% |
Biochemistry, Genetics and Molecular Biology | 9 | 22% |
Immunology and Microbiology | 4 | 10% |
Medicine and Dentistry | 2 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 3 | 7% |
Unknown | 5 | 12% |