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Engineering of papaya mosaic virus (PapMV) nanoparticles with a CTL epitope derived from influenza NP

Overview of attention for article published in Journal of Nanobiotechnology, April 2013
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Title
Engineering of papaya mosaic virus (PapMV) nanoparticles with a CTL epitope derived from influenza NP
Published in
Journal of Nanobiotechnology, April 2013
DOI 10.1186/1477-3155-11-10
Pubmed ID
Authors

Cindy Babin, Nathalie Majeau, Denis Leclerc

Abstract

The ever-present threat of infectious disease, e.g. influenza pandemics, and the increasing need for new and effective treatments in immunotherapy are the driving forces that motivate research into new and innovative vaccine platforms. Ideally, such platforms should trigger an efficient CTL response, be safe, and easy to manufacture. We recently developed a novel nanoparticle adjuvant comprised of papaya mosaic virus (PapMV) coat protein (CP) assembled around an RNA. The PapMV nanoparticle is an efficient vaccine platform in which the peptide antigen is fused to the C-terminus of the PapMV CP, leading to nanoparticles presenting surface-exposed epitope. The fusion stabilizes the epitope and improves its immunogenicity. We found recently that C-terminal fusions are not always efficient, depending on the nature of the peptide fused to the platform.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 5%
Unknown 39 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 24%
Student > Master 9 22%
Researcher 7 17%
Student > Bachelor 4 10%
Student > Doctoral Student 2 5%
Other 5 12%
Unknown 4 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 41%
Biochemistry, Genetics and Molecular Biology 9 22%
Immunology and Microbiology 4 10%
Medicine and Dentistry 2 5%
Nursing and Health Professions 1 2%
Other 3 7%
Unknown 5 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2013.
All research outputs
#14,623,075
of 22,705,019 outputs
Outputs from Journal of Nanobiotechnology
#576
of 1,395 outputs
Outputs of similar age
#118,438
of 199,685 outputs
Outputs of similar age from Journal of Nanobiotechnology
#5
of 6 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,395 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,685 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.