Title |
Effort required to finish shotgun-generated genome sequences differs significantly among vertebrates
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Published in |
BMC Genomics, January 2010
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DOI | 10.1186/1471-2164-11-21 |
Pubmed ID | |
Authors |
Robert W Blakesley, Nancy F Hansen, Jyoti Gupta, Jennifer C McDowell, Baishali Maskeri, Beatrice B Barnabas, Shelise Y Brooks, Holly Coleman, Payam Haghighi, Shi-Ling Ho, Karen Schandler, Sirintorn Stantripop, Jennifer L Vogt, Pamela J Thomas, NISC Comparative Sequencing Program, Gerard G Bouffard, Eric D Green |
Abstract |
The approaches for shotgun-based sequencing of vertebrate genomes are now well-established, and have resulted in the generation of numerous draft whole-genome sequence assemblies. In contrast, the process of refining those assemblies to improve contiguity and increase accuracy (known as 'sequence finishing') remains tedious, labor-intensive, and expensive. As a result, the vast majority of vertebrate genome sequences generated to date remain at a draft stage. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 12% |
Germany | 1 | 3% |
Brazil | 1 | 3% |
Norway | 1 | 3% |
Canada | 1 | 3% |
Sweden | 1 | 3% |
Unknown | 25 | 74% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 56% |
Student > Ph. D. Student | 6 | 18% |
Other | 3 | 9% |
Student > Master | 2 | 6% |
Student > Bachelor | 1 | 3% |
Other | 3 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 82% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Physics and Astronomy | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Unknown | 1 | 3% |