Title |
Treating cancer cachexia to treat cancer
|
---|---|
Published in |
Skeletal Muscle, January 2011
|
DOI | 10.1186/2044-5040-1-2 |
Pubmed ID | |
Authors |
Se-Jin Lee, David J Glass |
Abstract |
Skeletal muscle wasting is a major component of cachectic states found in a variety of disease settings, including cancer. As increasing caloric intake often provides little benefit in combating muscle loss in cachectic patients, a major research focus has been to develop strategies stimulating muscle anabolic pathways - in an attempt to fight the catabolic pathways induced during cachexia. Two recent papers have reported the beneficial effects of blocking the myostatin/activin signalling pathway in mouse models of cancer cachexia. We discuss the implications of their findings both with respect to the role that this signalling pathway may play in the aetiology of cachexia and with respect to the prospects for targeting this pathway as a therapeutic strategy in patients with cachexia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
Hungary | 1 | 2% |
Australia | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 55 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 20% |
Researcher | 8 | 13% |
Student > Master | 8 | 13% |
Student > Doctoral Student | 7 | 12% |
Student > Bachelor | 6 | 10% |
Other | 13 | 22% |
Unknown | 6 | 10% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 22 | 37% |
Medicine and Dentistry | 15 | 25% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Sports and Recreations | 2 | 3% |
Nursing and Health Professions | 1 | 2% |
Other | 3 | 5% |
Unknown | 10 | 17% |