Title |
Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks
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Published in |
Veterinary Research, January 2011
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DOI | 10.1186/1297-9716-42-5 |
Pubmed ID | |
Authors |
Gonnie Nodelijk, Herman JW van Roermund, Lucien JM van Keulen, Bas Engel, Piet Vellema, Thomas J Hagenaars |
Abstract |
Susceptibility to scrapie, a transmissible spongiform encephalopathy in sheep, is modulated by the genetic make-up of the sheep. Scrapie control policies, based on selecting animals of resistant genotype for breeding, have recently been adopted by the Netherlands and other European countries. Here we assess the effectiveness of a breeding programme based on selecting rams of resistant genotype to obtain outbreak control in classical scrapie-affected sheep flocks under field conditions. In six commercially-run flocks following this breeding strategy, we used genotyping to monitor the genotype distribution, and tonsil biopsies and post-mortem analyses to monitor the occurrence of scrapie infection. The farmers were not informed about the monitoring results until the end of the study period of six years. We used a mathematical model of scrapie transmission to analyze the monitoring data and found that where the breeding scheme was consistently applied, outbreak control was obtained after at most four years. Our results also show that classical scrapie control can be obtained before the frequency of non-resistant animals is reduced to zero in the flock. This suggests that control at the national scale can be obtained without a loss of genetic polymorphisms from any of the sheep breeds. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 25% |
Other | 3 | 15% |
Student > Bachelor | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Other | 3 | 15% |
Unknown | 3 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 8 | 40% |
Agricultural and Biological Sciences | 6 | 30% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Arts and Humanities | 1 | 5% |
Unknown | 4 | 20% |