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Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

Overview of attention for article published in Journal of Molecular Signaling, July 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
314 Dimensions

Readers on

mendeley
204 Mendeley
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Title
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
Published in
Journal of Molecular Signaling, July 2010
DOI 10.1186/1750-2187-5-10
Pubmed ID
Authors

Sanjit K Roy, Rakesh K Srivastava, Sharmila Shankar

Abstract

Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of several biological processes, including the stress resistance, metabolism, cell cycle, apoptosis and DNA repair. The objectives of this study were to examine the molecular mechanisms by which FOXO transcription factors induced cell cycle arrest and apoptosis and enhanced anti-proliferative effects of sulforaphane (SFN, an active compound in cruciferous vegetables) in pancreatic cancer cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Portugal 2 <1%
United Kingdom 2 <1%
South Africa 1 <1%
Canada 1 <1%
Germany 1 <1%
Unknown 194 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 20%
Researcher 38 19%
Student > Master 33 16%
Student > Doctoral Student 18 9%
Student > Bachelor 16 8%
Other 26 13%
Unknown 32 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 72 35%
Biochemistry, Genetics and Molecular Biology 54 26%
Medicine and Dentistry 22 11%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Immunology and Microbiology 2 <1%
Other 13 6%
Unknown 36 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2010.
All research outputs
#4,655,198
of 22,705,019 outputs
Outputs from Journal of Molecular Signaling
#3
of 44 outputs
Outputs of similar age
#19,566
of 95,594 outputs
Outputs of similar age from Journal of Molecular Signaling
#1
of 2 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 44 research outputs from this source. They receive a mean Attention Score of 2.6. This one scored the same or higher as 41 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them