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Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum

Overview of attention for article published in BMC Microbiology, February 2010
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

blogs
1 blog

Citations

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7 Dimensions

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21 Mendeley
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Title
Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum
Published in
BMC Microbiology, February 2010
DOI 10.1186/1471-2180-10-49
Pubmed ID
Authors

Meggan C Laskowski, Alan G Smulian

Abstract

Histoplasma capsulatum is a pathogenic ascomycete fungus that rapidly loses mating ability in culture. Loss of mating ability, as well as the organism's low rate of targeted gene replacement, limits techniques available for genetic studies in H. capsulatum. Understanding molecular mechanisms regulating mating in this organism may allow us to reverse or prevent loss of mating in H. capsulatum strains, introducing a variety of classical genetics techniques to the field. We generated a strain, UC1, by insertional mutagenesis of the laboratory strain G217B, and found that UC1 acquired the ability to form mating structures called cleistothecia. The aim of this study was to determine the mechanism by which UC1 gained the ability to form cleistothecia. We also present initial studies demonstrating that UC1 can be used as a tool to determine molecular correlates of mating in H. capsulatum.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 38%
Student > Ph. D. Student 6 29%
Student > Bachelor 2 10%
Student > Master 1 5%
Student > Postgraduate 1 5%
Other 0 0%
Unknown 3 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 48%
Biochemistry, Genetics and Molecular Biology 3 14%
Medicine and Dentistry 3 14%
Immunology and Microbiology 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 0 0%
Unknown 3 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2010.
All research outputs
#6,407,565
of 25,374,647 outputs
Outputs from BMC Microbiology
#652
of 3,489 outputs
Outputs of similar age
#30,355
of 102,893 outputs
Outputs of similar age from BMC Microbiology
#8
of 24 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 3,489 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.