Title |
Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain
|
---|---|
Published in |
Virology Journal, April 2013
|
DOI | 10.1186/1743-422x-10-116 |
Pubmed ID | |
Authors |
Sarah L Fordyce, Karoline Bragstad, Svend Stenvang Pedersen, Thøger G Jensen, Bente Gahrn-Hansen, Rod Daniels, Alan Hay, Marie-Louise Kampmann, Christian AW Bruhn, J Victor Moreno-Mayar, María C Ávila-Arcos, M Thomas P Gilbert, Lars P Nielsen |
Abstract |
Influenza viruses such as swine-origin influenza A(H1N1) virus (A(H1N1)pdm09) generate genetic diversity due to the high error rate of their RNA polymerase, often resulting in mixed genotype populations (intra-host variants) within a single infection. This variation helps influenza to rapidly respond to selection pressures, such as those imposed by the immunological host response and antiviral therapy. We have applied deep sequencing to characterize influenza intra-host variation in a transmission chain consisting of three cases due to oseltamivir-sensitive viruses, and one derived oseltamivir-resistant case. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Panama | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 47 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 22% |
Researcher | 11 | 22% |
Student > Bachelor | 8 | 16% |
Student > Doctoral Student | 4 | 8% |
Student > Master | 4 | 8% |
Other | 7 | 14% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 26 | 53% |
Biochemistry, Genetics and Molecular Biology | 8 | 16% |
Immunology and Microbiology | 3 | 6% |
Medicine and Dentistry | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 8% |
Unknown | 5 | 10% |