Title |
Brownian diffusion of AMPA receptors is sufficient to explain fast onset of LTP
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Published in |
BMC Systems Biology, March 2010
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DOI | 10.1186/1752-0509-4-25 |
Pubmed ID | |
Authors |
Dominic P Tolle, Nicolas Le Novère |
Abstract |
Long-Term Potentiation (LTP) of synapses is thought to be due in part to a change in AMPA Receptor trafficking leading to an increase in the number of AMPA Receptors at the synapse. LTP onset occurs within seconds after the induction signal. A particle-based stochastic simulation software is used to investigate the effect of Brownian diffusion of glutamate receptors on receptor incorporation into the synaptic specialisation and the time-course of LTP expression. The model of the dendritic spine includes receptors diffusing within the membrane, scaffold molecules within the synaptic specialisation capable of binding receptors and a molecular picket-fence surrounding the synaptic membrane area, all features found within the biological system. |
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