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Brownian diffusion of AMPA receptors is sufficient to explain fast onset of LTP

Overview of attention for article published in BMC Systems Biology, March 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

blogs
1 blog

Citations

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10 Dimensions

Readers on

mendeley
39 Mendeley
citeulike
2 CiteULike
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Title
Brownian diffusion of AMPA receptors is sufficient to explain fast onset of LTP
Published in
BMC Systems Biology, March 2010
DOI 10.1186/1752-0509-4-25
Pubmed ID
Authors

Dominic P Tolle, Nicolas Le Novère

Abstract

Long-Term Potentiation (LTP) of synapses is thought to be due in part to a change in AMPA Receptor trafficking leading to an increase in the number of AMPA Receptors at the synapse. LTP onset occurs within seconds after the induction signal. A particle-based stochastic simulation software is used to investigate the effect of Brownian diffusion of glutamate receptors on receptor incorporation into the synaptic specialisation and the time-course of LTP expression. The model of the dendritic spine includes receptors diffusing within the membrane, scaffold molecules within the synaptic specialisation capable of binding receptors and a molecular picket-fence surrounding the synaptic membrane area, all features found within the biological system.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
United Kingdom 1 3%
Netherlands 1 3%
Germany 1 3%
Unknown 35 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 33%
Student > Ph. D. Student 10 26%
Student > Master 4 10%
Student > Postgraduate 2 5%
Student > Bachelor 2 5%
Other 3 8%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 54%
Neuroscience 6 15%
Biochemistry, Genetics and Molecular Biology 3 8%
Medicine and Dentistry 3 8%
Business, Management and Accounting 1 3%
Other 1 3%
Unknown 4 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2010.
All research outputs
#5,477,369
of 22,707,247 outputs
Outputs from BMC Systems Biology
#172
of 1,142 outputs
Outputs of similar age
#26,552
of 94,146 outputs
Outputs of similar age from BMC Systems Biology
#6
of 15 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,142 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,146 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.