Title |
Responses of metastatic basal cell and cutaneous squamous cell carcinomas to anti-PD1 monoclonal antibody REGN2810
|
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Published in |
Journal for Immunotherapy of Cancer, November 2016
|
DOI | 10.1186/s40425-016-0176-3 |
Pubmed ID | |
Authors |
Gerald S. Falchook, Rom Leidner, Elizabeth Stankevich, Brian Piening, Carlo Bifulco, Israel Lowy, Matthew G. Fury |
Abstract |
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) share exposure to UV light as the dominant risk factor, and these tumors therefore harbor high mutation burdens. In other malignancies, high mutation burden has been associated with clinical benefit from therapy with antibodies directed against the Programmed Death 1 (PD-1) immune checkpoint receptor. Highly mutated tumors are more likely to express immunogenic tumor neoantigens that attract effector T cells, which can be unleashed by blockade of the PD-1 immune checkpoint. This report describes a patient with metastatic BCC and a patient with metastatic CSCC who were treated with REGN2810, a fully human anti-PD-1 monoclonal antibody, in an ongoing phase 1 trial (NCT02383212). The CSCC patient has experienced an ongoing complete response (16+ months), and the BCC patient has experienced an ongoing partial response (12+ months). These case reports suggest that UV-associated skin cancers, beyond melanoma, are sensitive to PD-1 blockade. Clinicaltrials.gov NCT02383212. Registered 2 February 2015. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 75% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 50% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Scientists | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 100 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 17% |
Student > Doctoral Student | 11 | 11% |
Other | 9 | 9% |
Student > Master | 9 | 9% |
Professor | 4 | 4% |
Other | 19 | 19% |
Unknown | 31 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 44 | 44% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Agricultural and Biological Sciences | 4 | 4% |
Immunology and Microbiology | 3 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 4 | 4% |
Unknown | 39 | 39% |