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Development of a method for environmentally friendly chemical peptide synthesis in water using water-dispersible amino acid nanoparticles

Overview of attention for article published in BMC Chemistry, August 2011
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Title
Development of a method for environmentally friendly chemical peptide synthesis in water using water-dispersible amino acid nanoparticles
Published in
BMC Chemistry, August 2011
DOI 10.1186/1752-153x-5-49
Pubmed ID
Authors

Keiko Hojo, Asaki Hara, Hiroyuki Kitai, Mare Onishi, Hideki Ichikawa, Yoshinobu Fukumori, Koichi Kawasaki

Abstract

Due to the vast importance of peptides in biological processes, there is an escalating need for synthetic peptides to be used in a wide variety of applications. However, the consumption of organic solvent is extremely large in chemical peptide syntheses because of the multiple condensation steps in organic solvents. That is, the current synthesis method is not environmentally friendly. From the viewpoint of green sustainable chemistry, we focused on developing an organic solvent-free synthetic method using water, an environmentally friendly solvent. Here we described in-water synthesis technology using water-dispersible protected amino acids.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 2 3%
India 1 1%
Netherlands 1 1%
Switzerland 1 1%
Unknown 70 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 24%
Student > Master 11 15%
Student > Bachelor 10 13%
Researcher 6 8%
Professor > Associate Professor 4 5%
Other 11 15%
Unknown 15 20%
Readers by discipline Count As %
Chemistry 34 45%
Agricultural and Biological Sciences 7 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Environmental Science 3 4%
Materials Science 3 4%
Other 8 11%
Unknown 17 23%