Title |
Current status of multiple antigen-presenting peptide vaccine systems: Application of organic and inorganic nanoparticles
|
---|---|
Published in |
BMC Chemistry, August 2011
|
DOI | 10.1186/1752-153x-5-48 |
Pubmed ID | |
Authors |
Yoshio Fujita, Hiroaki Taguchi |
Abstract |
Many studies are currently investigating the development of safe and effective vaccines to prevent various infectious diseases. Multiple antigen-presenting peptide vaccine systems have been developed to avoid the adverse effects associated with conventional vaccines (i.e., live-attenuated, killed or inactivated pathogens), carrier proteins and cytotoxic adjuvants. Recently, two main approaches have been used to develop multiple antigen-presenting peptide vaccine systems: (1) the addition of functional components, e.g., T-cell epitopes, cell-penetrating peptides, and lipophilic moieties; and (2) synthetic approaches using size-defined nanomaterials, e.g., self-assembling peptides, non-peptidic dendrimers, and gold nanoparticles, as antigen-displaying platforms. This review summarizes the recent experimental studies directed to the development of multiple antigen-presenting peptide vaccine systems. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Spain | 1 | 1% |
India | 1 | 1% |
Unknown | 89 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 18% |
Researcher | 15 | 16% |
Student > Bachelor | 13 | 14% |
Student > Master | 10 | 11% |
Student > Doctoral Student | 7 | 8% |
Other | 13 | 14% |
Unknown | 17 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 26% |
Chemistry | 16 | 17% |
Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Engineering | 4 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 16 | 17% |
Unknown | 20 | 22% |