Title |
The mathematics of tanning
|
---|---|
Published in |
BMC Systems Biology, June 2009
|
DOI | 10.1186/1752-0509-3-60 |
Pubmed ID | |
Authors |
Josef Thingnes, Leiv Øyehaug, Eivind Hovig, Stig W Omholt |
Abstract |
The pigment melanin is produced by specialized cells, called melanocytes. In healthy skin, melanocytes are sparsely spread among the other cell types in the basal layer of the epidermis. Sun tanning results from an UV-induced increase in the release of melanin to neighbouring keratinocytes, the major cell type component of the epidermis as well as redistribution of melanin among these cells. Here we provide a mathematical conceptualization of our current knowledge of the tanning response, in terms of a dynamic model. The resolution level of the model is tuned to available data, and its primary focus is to describe the tanning response following UV exposure. |
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