Title |
Brucella abortus induces TNF-α-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases
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Published in |
Journal of Neuroinflammation, April 2013
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DOI | 10.1186/1742-2094-10-47 |
Pubmed ID | |
Authors |
M Cruz Miraglia, Romina Scian, Clara García Samartino, Paula Barrionuevo, Ana M Rodriguez, Andrés E Ibañez, Lorena M Coria, Lis N Velásquez, Pablo C Baldi, Juliana Cassataro, M Victoria Delpino, Guillermo H Giambartolomei |
Abstract |
Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. We have recently demonstrated that B. abortus infects microglia and astrocytes, eliciting the production of a variety of pro-inflammatory cytokines which contribute to CNS damage. Matrix metalloproteinases (MMP) have been implicated in inflammatory tissue destruction in a range of pathological situations in the CNS. Increased MMP secretion is induced by pro-inflammatory cytokines in a variety of CNS diseases characterized by tissue-destructive pathology. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 25% |
Student > Bachelor | 4 | 14% |
Student > Ph. D. Student | 4 | 14% |
Student > Master | 2 | 7% |
Other | 2 | 7% |
Other | 3 | 11% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 21% |
Immunology and Microbiology | 5 | 18% |
Nursing and Health Professions | 3 | 11% |
Veterinary Science and Veterinary Medicine | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Other | 4 | 14% |
Unknown | 6 | 21% |