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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Development of a recombinant antibody to target peptides and proteins to sialoadhesin-expressing macrophages
|
|---|---|
| Published in |
BMC Biotechnology, April 2013
|
| DOI | 10.1186/1472-6750-13-33 |
| Pubmed ID | |
| Authors |
Karen Ooms, Hanne Van Gorp, Tim Van Gaever, Hans J Nauwynck, Peter L Delputte |
| Abstract |
Sialoadhesin (Sn)-expressing monocytes/macrophages have been associated with several diseases like inflammatory and autoimmune disorders as well as viral infections, and they also appear to play a role in the initiation of an adaptive immune response. This makes Sn-expressing cells not only attractive targets for cell-directed therapies, but also an appealing target for vaccination. Furthermore, since Sn was shown to be an endocytic receptor, the conjugation of effector molecules to an Sn-specific ligand should allow intracellular delivery of these conjugates. Previously, we developed functional Sn-specific immunoconjugates that were generated via chemical coupling. Although successful, the system requires significant optimization for each immunoconjugate to be made. To generate a more flexible and controlled system, we developed a recombinant antibody vector allowing the creation of genetic antibody fusion constructs. This paper reports on the characterization of the recombinant antibody and the evaluation of its use for Sn-directed targeting. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| Japan | 1 | 17% |
| Spain | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 2 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 4% |
| Germany | 1 | 4% |
| Belgium | 1 | 4% |
| Unknown | 23 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 35% |
| Student > Master | 4 | 15% |
| Professor | 3 | 12% |
| Other | 2 | 8% |
| Student > Postgraduate | 2 | 8% |
| Other | 5 | 19% |
| Unknown | 1 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 38% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 19% |
| Immunology and Microbiology | 2 | 8% |
| Social Sciences | 2 | 8% |
| Medicine and Dentistry | 2 | 8% |
| Other | 4 | 15% |
| Unknown | 1 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2013.
All research outputs
#6,560,526
of 23,881,329 outputs
Outputs from BMC Biotechnology
#367
of 937 outputs
Outputs of similar age
#53,923
of 201,724 outputs
Outputs of similar age from BMC Biotechnology
#3
of 19 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 937 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,724 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.