Title |
c-Met inhibitors
|
---|---|
Published in |
Infectious Agents and Cancer, April 2013
|
DOI | 10.1186/1750-9378-8-13 |
Pubmed ID | |
Authors |
Anum Mughal, Hafiz Muhammad Aslam, Asfandyar Sheikh, Agha Muhammad Hammad Khan, Shafaq Saleem |
Abstract |
c-Met is a receptor tyrosine kinase that encodes protein such as hepatocyte growth factor receptor (HGFR). Inappropriate activity of c-Met can cause wide variety of carcinomas. c-Met inhibitor are relatively new class of small molecules that inhibit the enzymatic activity of c-Met tyrosine kinase. Met inhibitors divided into two main classes: class I (SU-11274-like) and class II (AM7-like). The use of c-Met inhibitors with other therapeutic agents could be crucial for overcoming potential resistance as well as for improving overall clinical benefit. Met pathway inhibitors might be used in combination with other treatments, including chemo-, radio- or immunotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 3% |
United States | 1 | 3% |
Unknown | 29 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 32% |
Student > Ph. D. Student | 6 | 19% |
Student > Doctoral Student | 3 | 10% |
Researcher | 3 | 10% |
Other | 1 | 3% |
Other | 3 | 10% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 23% |
Medicine and Dentistry | 6 | 19% |
Chemistry | 5 | 16% |
Agricultural and Biological Sciences | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
Other | 0 | 0% |
Unknown | 7 | 23% |