Title |
Respiratory viral infections and host responses; insights from genomics
|
---|---|
Published in |
Respiratory Research, November 2016
|
DOI | 10.1186/s12931-016-0474-9 |
Pubmed ID | |
Authors |
Niamh M. Troy, Anthony Bosco |
Abstract |
Respiratory viral infections are a leading cause of disease and mortality. The severity of these illnesses can vary markedly from mild or asymptomatic upper airway infections to severe wheezing, bronchiolitis or pneumonia. In this article, we review the viral sensing pathways and organizing principles that govern the innate immune response to infection. Then, we reconstruct the molecular networks that differentiate symptomatic from asymptomatic respiratory viral infections, and identify the underlying molecular drivers of these networks. Finally, we discuss unique aspects of the biology and pathogenesis of infections with respiratory syncytial virus, rhinovirus and influenza, drawing on insights from genomics. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Venezuela, Bolivarian Republic of | 3 | 20% |
United Kingdom | 3 | 20% |
United States | 2 | 13% |
Uruguay | 1 | 7% |
Canada | 1 | 7% |
Mexico | 1 | 7% |
Spain | 1 | 7% |
Argentina | 1 | 7% |
Unknown | 2 | 13% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 73% |
Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Scientists | 1 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 153 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 16% |
Researcher | 24 | 16% |
Student > Bachelor | 18 | 12% |
Student > Master | 15 | 10% |
Student > Doctoral Student | 11 | 7% |
Other | 23 | 15% |
Unknown | 39 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 19% |
Biochemistry, Genetics and Molecular Biology | 25 | 16% |
Immunology and Microbiology | 23 | 15% |
Agricultural and Biological Sciences | 13 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 16 | 10% |
Unknown | 45 | 29% |