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Drugging Hedgehog: signaling the pathway to translation

Overview of attention for article published in BMC Biology, April 2013
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Title
Drugging Hedgehog: signaling the pathway to translation
Published in
BMC Biology, April 2013
DOI 10.1186/1741-7007-11-37
Pubmed ID
Authors

Tom J Carney, Philip W Ingham

Abstract

First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.

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Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
India 1 2%
France 1 2%
Singapore 1 2%
Unknown 61 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 29%
Researcher 12 18%
Student > Master 8 12%
Professor 5 8%
Student > Postgraduate 5 8%
Other 11 17%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 35%
Biochemistry, Genetics and Molecular Biology 18 28%
Medicine and Dentistry 9 14%
Chemistry 3 5%
Psychology 2 3%
Other 4 6%
Unknown 6 9%