Title |
Modular glycosphere assays for high-throughput functional characterization of influenza viruses
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Published in |
BMC Biotechnology, April 2013
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DOI | 10.1186/1472-6750-13-34 |
Pubmed ID | |
Authors |
Sven N Hobbie, Karthik Viswanathan, Ido Bachelet, Udayanath Aich, Zachary Shriver, Vidya Subramanian, Rahul Raman, Ram Sasisekharan |
Abstract |
The ongoing global efforts to control influenza epidemics and pandemics require high-throughput technologies to detect, quantify, and functionally characterize viral isolates. The 2009 influenza pandemic as well as the recent in-vitro selection of highly transmissible H5N1 variants have only increased existing concerns about emerging influenza strains with significantly enhanced human-to-human transmissibility. High-affinity binding of the virus hemagglutinin to human receptor glycans is a highly sensitive and stringent indicator of host adaptation and virus transmissibility. The surveillance of receptor-binding characteristics can therefore provide a strong additional indicator for the relative hazard imposed by circulating and newly emerging influenza strains. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 32% |
Student > Bachelor | 3 | 16% |
Professor | 2 | 11% |
Student > Master | 2 | 11% |
Professor > Associate Professor | 2 | 11% |
Other | 2 | 11% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 42% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Immunology and Microbiology | 2 | 11% |
Computer Science | 1 | 5% |
Mathematics | 1 | 5% |
Other | 2 | 11% |
Unknown | 3 | 16% |