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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
|
|---|---|
| Published in |
BMC Gastroenterology, April 2013
|
| DOI | 10.1186/1471-230x-13-67 |
| Pubmed ID | |
| Authors |
Chaofeng Yang, Weiqin Lu, Tao Lin, Pan You, Min Ye, Yanqing Huang, Xianhan Jiang, Cong Wang, Fen Wang, Mong-Hong Lee, Sai-Ching J Yeung, Randy L Johnson, Chongjuan Wei, Robert Y Tsai, Marsha L Frazier, Wallace L McKeehan, Yongde Luo |
| Abstract |
FGF21 is a promising intervention therapy for metabolic diseases as fatty liver, obesity and diabetes. Recent results suggest that FGF21 is highly expressed in hepatocytes under metabolic stress caused by starvation, hepatosteatosis, obesity and diabetes. Hepatic FGF21 elicits metabolic benefits by targeting adipocytes of the peripheral adipose tissue through the transmembrane FGFR1-KLB complex. Ablation of adipose FGFR1 resulted in increased hepatosteatosis under starvation conditions and abrogation of the anti-obesogenic action of FGF21. These results indicate that FGF21 may be a stress responsive hepatokine that targets adipocytes and adipose tissue for alleviating the damaging effects of stress on the liver. However, it is unclear whether hepatic induction of FGF21 is limited to only metabolic stress, or to a more general hepatic stress resulting from liver pathogenesis and injury. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Denmark | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 109 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 16% |
| Student > Ph. D. Student | 17 | 15% |
| Student > Bachelor | 16 | 14% |
| Researcher | 13 | 11% |
| Student > Postgraduate | 7 | 6% |
| Other | 25 | 22% |
| Unknown | 18 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 28% |
| Medicine and Dentistry | 25 | 22% |
| Biochemistry, Genetics and Molecular Biology | 21 | 18% |
| Immunology and Microbiology | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 6 | 5% |
| Unknown | 23 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2015.
All research outputs
#15,270,134
of 22,707,247 outputs
Outputs from BMC Gastroenterology
#830
of 1,731 outputs
Outputs of similar age
#123,467
of 197,532 outputs
Outputs of similar age from BMC Gastroenterology
#24
of 33 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,731 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,532 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.