Title |
Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas
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Published in |
BMC Veterinary Research, April 2013
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DOI | 10.1186/1746-6148-9-80 |
Pubmed ID | |
Authors |
Lorella Maniscalco, Yolanda Millán, Selina Iussich, Mauro Denina, Raquel Sánchez-Céspedes, Francesca Gattino, Bartolomeo Biolatti, Nobuo Sasaki, Takayuki Nakagawa, Maria Flavia Di Renzo, Juana Martín de las Mulas, Raffaella De Maria |
Abstract |
Triple negative breast cancer (TNBC) in humans is defined by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 overexpression. Mammalian target of rapamycin (mTOR) is overexpressed in TNBC and it represents a potential target for the treatment of this aggressive tumour. Feline mammary carcinoma (FMC) is considered to be a model for hormone-independent human breast cancer. This study investigated mTOR and p-mTOR expression in FMC in relation to triple negative (TN) phenotype. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 2% |
Portugal | 1 | 2% |
Unknown | 43 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 8 | 18% |
Researcher | 6 | 13% |
Student > Master | 6 | 13% |
Student > Bachelor | 4 | 9% |
Student > Doctoral Student | 4 | 9% |
Other | 12 | 27% |
Unknown | 5 | 11% |
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Veterinary Science and Veterinary Medicine | 18 | 40% |
Medicine and Dentistry | 11 | 24% |
Agricultural and Biological Sciences | 4 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Unspecified | 1 | 2% |
Other | 0 | 0% |
Unknown | 8 | 18% |