Title |
Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
|
---|---|
Published in |
Genome Integrity, April 2013
|
DOI | 10.1186/2041-9414-4-3 |
Pubmed ID | |
Authors |
Nobuo Horikoshi, Pankaj Kumar, Girdhar G Sharma, Min Chen, Clayton R Hunt, Kenneth Westover, Shantanu Chowdhury, Tej K Pandita |
Abstract |
Histone post-translational modifications are critical determinants of chromatin structure and function, impacting multiple biological processes including DNA transcription, replication, and repair. The post-translational acetylation of histone H4 at lysine 16 (H4K16ac) was initially identified in association with dosage compensation of the Drosophila male X chromosome. However, in mammalian cells, H4K16ac is not associated with dosage compensation and the genomic distribution of H4K16ac is not precisely known. Therefore, we have mapped the genome-wide H4K16ac distribution in human cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 1 | 2% |
India | 1 | 2% |
China | 1 | 2% |
Korea, Republic of | 1 | 2% |
United States | 1 | 2% |
Unknown | 61 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 39% |
Professor | 9 | 14% |
Student > Master | 8 | 12% |
Researcher | 6 | 9% |
Student > Bachelor | 4 | 6% |
Other | 8 | 12% |
Unknown | 5 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 34 | 52% |
Biochemistry, Genetics and Molecular Biology | 18 | 27% |
Medicine and Dentistry | 2 | 3% |
Unspecified | 1 | 2% |
Earth and Planetary Sciences | 1 | 2% |
Other | 3 | 5% |
Unknown | 7 | 11% |