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Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression

Overview of attention for article published in Genome Integrity, April 2013
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Title
Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
Published in
Genome Integrity, April 2013
DOI 10.1186/2041-9414-4-3
Pubmed ID
Authors

Nobuo Horikoshi, Pankaj Kumar, Girdhar G Sharma, Min Chen, Clayton R Hunt, Kenneth Westover, Shantanu Chowdhury, Tej K Pandita

Abstract

Histone post-translational modifications are critical determinants of chromatin structure and function, impacting multiple biological processes including DNA transcription, replication, and repair. The post-translational acetylation of histone H4 at lysine 16 (H4K16ac) was initially identified in association with dosage compensation of the Drosophila male X chromosome. However, in mammalian cells, H4K16ac is not associated with dosage compensation and the genomic distribution of H4K16ac is not precisely known. Therefore, we have mapped the genome-wide H4K16ac distribution in human cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 2%
India 1 2%
China 1 2%
Korea, Republic of 1 2%
United States 1 2%
Unknown 61 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 39%
Professor 9 14%
Student > Master 8 12%
Researcher 6 9%
Student > Bachelor 4 6%
Other 8 12%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 52%
Biochemistry, Genetics and Molecular Biology 18 27%
Medicine and Dentistry 2 3%
Unspecified 1 2%
Earth and Planetary Sciences 1 2%
Other 3 5%
Unknown 7 11%