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Mendeley readers
Attention Score in Context
| Title |
Identified in blood diet-related methylation changes stratify liver biopsies of NAFLD patients according to fibrosis grade
|
|---|---|
| Published in |
Clinical Epigenetics, November 2022
|
| DOI | 10.1186/s13148-022-01377-6 |
| Pubmed ID | |
| Authors |
Katarzyna Ewa Sokolowska, Dominika Maciejewska-Markiewicz, Jan Bińkowski, Joanna Palma, Olga Taryma-Leśniak, Katarzyna Kozlowska-Petriczko, Konrad Borowski, Magdalena Baśkiewicz-Hałasa, Viktoria Hawryłkowicz, Patrycja Załęcka, Marcin Ufnal, Dominik Strapagiel, Justyna Jarczak, Karolina Skonieczna-Żydecka, Karina Ryterska, Bogusław Machaliński, Tomasz Kazimierz Wojdacz, Ewa Stachowska |
| Abstract |
High caloric diet and lack of physical activity are considered main causes of NAFLD, and a change in the diet is still the only effective treatment of this disease. However, molecular mechanism of the effectiveness of diet change in treatment of NAFLD is poorly understood. We aimed to assess the involvement of epigenetic mechanisms of gene expression regulation in treatment of NAFLD. Eighteen participants with medium- to high-grade steatosis were recruited and trained to follow the Mediterranean diet modified to include fibre supplements. At three timepoints (baseline, after 30 and 60 days), we evaluated adherence to the diet and measured a number of physiological parameters such as anthropometry, blood and stool biochemistry, liver steatosis and stiffness. We also collected whole blood samples for genome-wide methylation profiling and histone acetylation assessment. The diet change resulted in a decrease in liver steatosis along with statistically significant, but a minor change in BMI and weight of our study participants. The epigenetic profiling of blood cells identified significant genome-wide changes of methylation and acetylation with the former not involving regions directly regulating gene expression. Most importantly, we were able to show that identified blood methylation changes occur also in liver cells of NAFLD patients and the machine learning-based classifier that we build on those methylation changes was able to predict the stage of liver fibrosis with ROC AUC = 0.9834. Methylomes of blood cells from NAFLD patients display a number of changes that are most likely a consequence of unhealthy diet, and the diet change appears to reverse those epigenetic changes. Moreover, the methylation status at CpG sites undergoing diet-related methylation change in blood cells stratifies liver biopsies from NAFLD patients according to fibrosis grade. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 1 | 9% |
| Student > Ph. D. Student | 1 | 9% |
| Professor > Associate Professor | 1 | 9% |
| Unknown | 8 | 73% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 9% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Nursing and Health Professions | 1 | 9% |
| Neuroscience | 1 | 9% |
| Unknown | 7 | 64% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2022.
All research outputs
#15,565,989
of 23,905,714 outputs
Outputs from Clinical Epigenetics
#846
of 1,334 outputs
Outputs of similar age
#231,616
of 462,728 outputs
Outputs of similar age from Clinical Epigenetics
#31
of 56 outputs
Altmetric has tracked 23,905,714 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,334 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 462,728 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.