Title |
The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells
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Published in |
Respiratory Research, January 2005
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DOI | 10.1186/1465-9921-6-9 |
Pubmed ID | |
Authors |
Farhat Syed, Reynold A Panettieri, Omar Tliba, Chris Huang, Katherine Li, Michelle Bracht, Bernard Amegadzie, Don Griswold, Li Li, Yassine Amrani |
Abstract |
Growing evidence shows that interleukin 13 (IL-13) may play an essential role in the development of airway inflammation and bronchial hyper-responsiveness (BHR), two defining features of asthma. Although the underlying mechanisms remain unknown, a number of reports have shown that IL-13 may exert its deleterious effects in asthma by directly acting on airway resident cells, including epithelial cells and airway smooth muscle cells. In this report, we hypothesize that IL-13 may participate in the pathogenesis of asthma by activating a set of "pro-asthmatic" genes in airway smooth muscle (ASM) cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 35% |
Other | 3 | 18% |
Student > Master | 2 | 12% |
Lecturer | 1 | 6% |
Professor | 1 | 6% |
Other | 3 | 18% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 35% |
Biochemistry, Genetics and Molecular Biology | 4 | 24% |
Medicine and Dentistry | 3 | 18% |
Chemistry | 1 | 6% |
Unknown | 3 | 18% |