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Shear rate specific blood viscosity and shear stress of carotid artery duplex ultrasonography in patients with lacunar infarction

Overview of attention for article published in BMC Neurology, April 2013
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Title
Shear rate specific blood viscosity and shear stress of carotid artery duplex ultrasonography in patients with lacunar infarction
Published in
BMC Neurology, April 2013
DOI 10.1186/1471-2377-13-36
Pubmed ID
Authors

Seul-Ki Jeong, Robert S Rosenson

Abstract

BACKGROUND: This study describes a new method for determining site-specific vascular shear stress using dynamic measures of shear rate and blood viscosity (BV) in the carotid arteries, and examines characteristics of carotid arterial shear stress among patients with lacunar infarction. METHODS: Vascular shear stress measurements were conducted in 37 patients (17 lacunar infarction patients and 20 control subjects) using duplex ultrasonography. Vessel wall diameters and velocities were measured in each arterial segment at peak-systolic (PS) and end-diastolic (ED) phases, for calculation of PS/ED shear rates. PS/ED shear stresses [dyne/cm2] were determined with PS/ED shear rates and shear-rate dependent BV values. For comparison, both values of hematocrit-derived BV and BV measurements at 300 s-1 were used for calculation of shear stress. RESULTS: All cardiovascular disease (CVD) risk factors including BV values were similar between the two groups. In both common carotid arteries, PS and ED shear stresses were significantly lower in the patients with lacunar infarction than in controls in multivariate models that included age, sex, and other major CVD risk factors. PS and ED shear stresses using the shear rate specific BV were 4.5% lower and 7.3% higher than those using the two other BVs, respectively. CONCLUSION: Lacunar infarction was associated with reduced carotid arterial shear stress. The use of estimated BV for calculating carotid arterial shear stress provides more accurate assessment of the hemodynamic contribution of shear stress than previous models that have arbitrarily assigned a constant value to this dynamic flow property.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 29%
Student > Bachelor 10 16%
Student > Ph. D. Student 7 11%
Researcher 6 10%
Student > Doctoral Student 3 5%
Other 8 13%
Unknown 10 16%
Readers by discipline Count As %
Engineering 21 34%
Medicine and Dentistry 6 10%
Agricultural and Biological Sciences 5 8%
Biochemistry, Genetics and Molecular Biology 3 5%
Chemistry 3 5%
Other 10 16%
Unknown 14 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2013.
All research outputs
#15,270,134
of 22,707,247 outputs
Outputs from BMC Neurology
#1,480
of 2,423 outputs
Outputs of similar age
#123,426
of 197,463 outputs
Outputs of similar age from BMC Neurology
#22
of 31 outputs
Altmetric has tracked 22,707,247 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,423 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,463 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.