Title |
TPH1A218C polymorphism and temperament in major depression
|
---|---|
Published in |
BMC Psychiatry, April 2013
|
DOI | 10.1186/1471-244x-13-118 |
Pubmed ID | |
Authors |
Kadri Andre, Olli Kampman, Merja Viikki, Ari Illi, Eija Setälä-Soikkeli, Outi Poutanen, Nina Mononen, Esa Leinonen, Terho Lehtimäki |
Abstract |
In major depression, one of the candidate genes possibly affecting the risk and severity of symptoms has been found to be tryptophan hydroxylase (TPH1). Variation in treatment response to antidepressive agents according to TPH1 genotype has also been found in several studies. However, the relationship between temperament and TPH1 genotype in major depression is poorly understood, as only one study has been published so far. There are no earlier studies on the interaction between temperament traits, antidepressive medication response and TPH1 genotype. This interaction was studied in 97 subjects with major depression treated for six weeks with selective serotonine reuptake inhibitors. |
X Demographics
Geographical breakdown
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Egypt | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 20% |
Student > Doctoral Student | 5 | 13% |
Student > Bachelor | 5 | 13% |
Student > Master | 5 | 13% |
Student > Ph. D. Student | 5 | 13% |
Other | 5 | 13% |
Unknown | 7 | 18% |
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Medicine and Dentistry | 3 | 8% |
Other | 2 | 5% |
Unknown | 11 | 28% |