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Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review

Overview of attention for article published in Translational Neurodegeneration, April 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

6 tweeters


43 Dimensions

Readers on

186 Mendeley
1 CiteULike
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Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review
Published in
Translational Neurodegeneration, April 2013
DOI 10.1186/2047-9158-2-8
Pubmed ID

Xiao-dong Pan, Xiao-chun Chen


Frontotemporal lobar degeneration (FTLD) represents a group of clinically, neuropathologically and genetically heterogeneous disorders with plenty of overlaps between the neurodegenerative mechanism and the clinical phenotype. FTLD is pathologically characterized by the frontal and temporal lobar atrophy. Frontotemporal dementia (FTD) clinically presents with abnormalities of behavior and personality and language impairments variants. The clinical spectrum of FTD encompasses distinct canonical syndromes: behavioural variant of FTD (bvFTD) and primary progressive aphasia. The later includes nonfluent/agrammatic variant PPA (nfvPPA or PNFA), semantic variant PPA (svPPA or SD) and logopenic variant PPA (lvPPA). In addition, there is also overlap of FTD with motor neuron disease (FTD-MND or FTD-ALS), as well as the parkinsonian syndromes, progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). The FTLD spectrum disorders are based upon the predominant neuropathological proteins (containing inclusions of hyperphosphorylated tau or ubiquitin protein, e.g transactive response (TAR) DNA-binding protein 43 kDa (TDP-43) and fusedin-sarcoma protein in neurons and glial cells) into three main categories: (1) microtubule-associated protein tau (FTLD-Tau); (2) TAR DNA-binding protein-43 (FTLD-TDP); and (3) fused in sarcoma protein (FTLD-FUS). There are five main genes mutations leading clinical and pathological variants in FTLD that identified by molecular genetic studies, which are chromosome 9 open reading frame 72 (C9ORF72) gene, granulin (GRN) gene, microtubule associated protein tau gene (MAPT), the gene encoding valosin-containing protein (VCP) and the charged multivesicular body protein 2B (CHMP2B). In this review, recent advances on the different clinic variants, neuroimaging, genetics, pathological subtypes and clinicopathological associations of FTD will be discussed.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 186 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Spain 2 1%
Ecuador 1 <1%
Australia 1 <1%
Colombia 1 <1%
Mexico 1 <1%
Portugal 1 <1%
United Kingdom 1 <1%
Philippines 1 <1%
Other 0 0%
Unknown 174 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 17%
Student > Master 29 16%
Student > Bachelor 26 14%
Student > Ph. D. Student 23 12%
Student > Postgraduate 19 10%
Other 40 22%
Unknown 18 10%
Readers by discipline Count As %
Medicine and Dentistry 57 31%
Agricultural and Biological Sciences 38 20%
Neuroscience 26 14%
Psychology 17 9%
Biochemistry, Genetics and Molecular Biology 9 5%
Other 15 8%
Unknown 24 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2013.
All research outputs
of 11,316,164 outputs
Outputs from Translational Neurodegeneration
of 110 outputs
Outputs of similar age
of 130,169 outputs
Outputs of similar age from Translational Neurodegeneration
of 2 outputs
Altmetric has tracked 11,316,164 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 110 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.9. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 130,169 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them