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Mendeley readers
Attention Score in Context
| Title |
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
|
|---|---|
| Published in |
Molecular Neurodegeneration, April 2013
|
| DOI | 10.1186/1750-1326-8-13 |
| Pubmed ID | |
| Authors |
Jason D Ulrich, Jack M Burchett, Jessica L Restivo, Dorothy R Schuler, Philip B Verghese, Thomas E Mahan, Gary E Landreth, Joseph M Castellano, Hong Jiang, John R Cirrito, David M Holtzman |
| Abstract |
The APOE4 allele variant is the strongest known genetic risk factor for developing late-onset Alzheimer's disease. The link between apolipoprotein E (apoE) and Alzheimer's disease is likely due in large part to the impact of apoE on the metabolism of amyloid β (Aβ) within the brain. Manipulation of apoE levels and lipidation within the brain has been proposed as a therapeutic target for the treatment of Alzheimer's disease. However, we know little about the dynamic regulation of apoE levels and lipidation within the central nervous system. We have developed an assay to measure apoE levels in the brain interstitial fluid of awake and freely moving mice using large molecular weight cut-off microdialysis probes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 21% |
| Student > Ph. D. Student | 24 | 20% |
| Student > Master | 14 | 12% |
| Professor | 9 | 7% |
| Student > Doctoral Student | 8 | 7% |
| Other | 18 | 15% |
| Unknown | 22 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 19% |
| Agricultural and Biological Sciences | 22 | 18% |
| Medicine and Dentistry | 11 | 9% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Other | 21 | 17% |
| Unknown | 28 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2013.
All research outputs
#17,687,135
of 22,708,120 outputs
Outputs from Molecular Neurodegeneration
#759
of 844 outputs
Outputs of similar age
#143,023
of 197,527 outputs
Outputs of similar age from Molecular Neurodegeneration
#2
of 6 outputs
Altmetric has tracked 22,708,120 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 844 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,527 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.