Title |
A neural extracellular matrix-based method for in vitrohippocampal neuron culture and dopaminergic differentiation of neural stem cells
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Published in |
BMC Neuroscience, April 2013
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DOI | 10.1186/1471-2202-14-48 |
Pubmed ID | |
Authors |
Patricia García-Parra, Marcos Maroto, Fabio Cavaliere, Neia Naldaiz-Gastesi, José Iñaki Álava, Antonio G García, Adolfo López de Munain, Ander Izeta |
Abstract |
The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro. An organized neural extracellular matrix (nECM) promotes neural cell adhesion, proliferation and differentiation. Here, we expanded previous observations on the ability of nECM to support in vitro neuronal differentiation, with the following goals: (i) to recreate complex neuronal networks of embryonic rat hippocampal cells, and (ii) to achieve improved levels of dopaminergic differentiation of subventricular zone (SVZ) neural progenitor cells. |
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Unknown | 1 | 33% |
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Mendeley readers
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Researcher | 14 | 21% |
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