Title |
Activating mutations and senescence secretome: new insights into HER2 activation, drug sensitivity and metastatic progression
|
---|---|
Published in |
Breast Cancer Research, April 2013
|
DOI | 10.1186/bcr3406 |
Pubmed ID | |
Authors |
Swarnali Acharyya |
Abstract |
HER2 amplification and overexpression is observed in approximately 20% of breast cancers and is strongly associated with poor prognosis and therapeutic responsiveness to HER2 targeted agents. A recent study by Bose and colleagues suggests that another subset of breast cancer patients without HER2 amplification but with activating HER2 mutation might also benefit from existing HER2-targeted agents and the authors functionally characterize these somatic mutations in experimental models. In a second study on HER2-driven breast cancer, Angelini and colleagues investigate how the constitutively active, truncated carboxy-terminal fragment of HER2, p95HER2, promotes metastatic progression through non-cellautonomous secretion of factors from senescent cells. These new findings advance our understanding of HER2 biology in the context of HER2 activation as well as offer new insights into our understanding of drug sensitivity and metastatic progression. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 6% |
Unknown | 17 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 28% |
Researcher | 3 | 17% |
Other | 2 | 11% |
Student > Bachelor | 1 | 6% |
Lecturer | 1 | 6% |
Other | 2 | 11% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 33% |
Biochemistry, Genetics and Molecular Biology | 4 | 22% |
Agricultural and Biological Sciences | 2 | 11% |
Psychology | 1 | 6% |
Nursing and Health Professions | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 22% |