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In vivo cardiovascular magnetic resonance of 2D vessel wall diffusion anisotropy in carotid arteries

Overview of attention for article published in Critical Reviews in Diagnostic Imaging, November 2016
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Title
In vivo cardiovascular magnetic resonance of 2D vessel wall diffusion anisotropy in carotid arteries
Published in
Critical Reviews in Diagnostic Imaging, November 2016
DOI 10.1186/s12968-016-0304-8
Pubmed ID
Authors

Peter Opriessnig, Harald Mangge, Rudolf Stollberger, Hannes Deutschmann, Gernot Reishofer

Abstract

Diffusion weighted (DW) cardiovascular magnetic resonance (CMR) has shown great potential to discriminate between healthy and diseased vessel tissue by evaluating the apparent diffusion coefficient (ADC) along the arterial axis. Recently, ex vivo studies on porcine arteries utilizing diffusion tensor imaging (DTI) revealed a circumferential fiber orientation rather than an organization in axial direction, suggesting dominant diffusion perpendicular to the slice direction. In the present study, we propose a method to access tangential and radial diffusion of carotids in vivo by utilizing a pulse sequence that enables high resolution DW imaging in combination with a two-dimensional (2D) diffusion gradient direction sampling scheme perpendicular to the longitudinal axis of the artery. High resolution DTI of 12 healthy male volunteers (age: 25-60 years) was performed on one selected axial slice using a read-out segmented EPI (rs-EPI) sequence on a 3T MR scanner. It was found consistently for all 12 volunteers, that the tangential component as the principle direction of diffusion. Mean vessel wall fractional anisotropy (FA) values ranged from 0.7 for the youngest to 0.56 for the oldest participant. Linear regression analysis between the FA values and volunteers age revealed a highly significant (P < 0.01) linear relationship with an adjusted R(2) of 0.52. In addition, a linear trend (P < 0.1) could be observed between radial diffusivity (RD) and age. These results point to FA being a sensitive parameter able to capture changes in the vascular architecture with age. In detail, the data demonstrate a decrease in FA with advancing age indicating possible alterations of tissue microstructural integrity. Moreover, analyzing 2D diffusion tensor directions is sufficient and applicable in a clinical setup concerning the overall scan time.

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The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Researcher 5 15%
Student > Doctoral Student 3 9%
Student > Postgraduate 3 9%
Student > Bachelor 3 9%
Other 6 18%
Unknown 6 18%
Readers by discipline Count As %
Engineering 13 38%
Medicine and Dentistry 5 15%
Physics and Astronomy 2 6%
Neuroscience 2 6%
Social Sciences 1 3%
Other 2 6%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2017.
All research outputs
#7,408,676
of 25,522,520 outputs
Outputs from Critical Reviews in Diagnostic Imaging
#575
of 1,379 outputs
Outputs of similar age
#122,506
of 416,101 outputs
Outputs of similar age from Critical Reviews in Diagnostic Imaging
#17
of 30 outputs
Altmetric has tracked 25,522,520 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,379 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,101 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.