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X Demographics
Mendeley readers
Attention Score in Context
| Title |
TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction
|
|---|---|
| Published in |
Cardiovascular Diabetology, April 2013
|
| DOI | 10.1186/1475-2840-12-69 |
| Pubmed ID | |
| Authors |
Jing Sun, Yunfei Pu, Peijian Wang, Sijiao Chen, Yu Zhao, Chan Liu, Qianhui Shang, Zhiming Zhu, Daoyan Liu |
| Abstract |
Diabetic cardiovascular complications are characterised by oxidative stress-induced endothelial dysfunction. Uncoupling protein 2 (UCP2) is a regulator of mitochondrial reactive oxygen species (ROS) generation and can antagonise oxidative stress, but approaches that enhance the activity of UCP2 to inhibit ROS are scarce. Our previous studies show that activation of transient receptor potential vanilloid 1 (TRPV1) by capsaicin can prevent cardiometabolic disorders. In this study, we conducted experiments in vitro and in vivo to investigate the effect of capsaicin treatment on endothelial UCP2 and oxidative stress. We hypothesised that TRPV1 activation by capsaicin attenuates hyperglycemia-induced endothelial dysfunction through a UCP2-mediated antioxidant effect. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Chile | 1 | 2% |
| Unknown | 55 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 19% |
| Researcher | 10 | 18% |
| Student > Master | 7 | 12% |
| Student > Doctoral Student | 5 | 9% |
| Student > Ph. D. Student | 4 | 7% |
| Other | 7 | 12% |
| Unknown | 13 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 25% |
| Medicine and Dentistry | 9 | 16% |
| Agricultural and Biological Sciences | 7 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Nursing and Health Professions | 3 | 5% |
| Other | 6 | 11% |
| Unknown | 15 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2013.
All research outputs
#14,168,910
of 22,708,120 outputs
Outputs from Cardiovascular Diabetology
#705
of 1,366 outputs
Outputs of similar age
#111,856
of 196,447 outputs
Outputs of similar age from Cardiovascular Diabetology
#2
of 10 outputs
Altmetric has tracked 22,708,120 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,366 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,447 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.