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A prospective observational cohort study in primary care practices to identify factors associated with treatment failure in Staphylococcus aureus skin and soft tissue infections

Overview of attention for article published in Annals of Clinical Microbiology and Antimicrobials, November 2016
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Title
A prospective observational cohort study in primary care practices to identify factors associated with treatment failure in Staphylococcus aureus skin and soft tissue infections
Published in
Annals of Clinical Microbiology and Antimicrobials, November 2016
DOI 10.1186/s12941-016-0175-8
Pubmed ID
Authors

Grace C. Lee, Ronald G. Hall, Natalie K. Boyd, Steven D. Dallas, Liem C. Du, Lucina B. Treviño, Sylvia B. Treviño, Chad Retzloff, Kenneth A. Lawson, James Wilson, Randall J. Olsen, Yufeng Wang, Christopher R. Frei

Abstract

The incidence of outpatient visits for skin and soft tissue infections (SSTIs) has substantially increased over the last decade. The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has made the management of S. aureus SSTIs complex and challenging. The objective of this study was to identify risk factors contributing to treatment failures associated with community-associated S. aureus skin and soft tissue infections SSTIs. This was a prospective, observational study among 14 primary care clinics within the South Texas Ambulatory Research Network. The primary outcome was treatment failure within 90 days of the initial visit. Univariate associations between the explanatory variables and treatment failure were examined. A generalized linear mixed-effect model was developed to identify independent risk factors associated with treatment failure. Overall, 21% (22/106) patients with S. aureus SSTIs experienced treatment failure. The occurrence of treatment failure was similar among patients with methicillin-resistant S. aureus and those with methicillin-susceptible S. aureus SSTIs (19 vs. 24%; p = 0.70). Independent predictors of treatment failure among cases with S. aureus SSTIs was a duration of infection of ≥7 days prior to initial visit [aOR, 6.02 (95% CI 1.74-19.61)] and a lesion diameter size ≥5 cm [5.25 (1.58-17.20)]. Predictors for treatment failure included a duration of infection for ≥7 days prior to the initial visit and a wound diameter of ≥5 cm. A heightened awareness of these risk factors could help direct targeted interventions in high-risk populations.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 13%
Researcher 4 13%
Student > Bachelor 3 10%
Student > Master 3 10%
Student > Doctoral Student 2 6%
Other 7 23%
Unknown 8 26%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 19%
Medicine and Dentistry 6 19%
Agricultural and Biological Sciences 4 13%
Nursing and Health Professions 2 6%
Environmental Science 1 3%
Other 2 6%
Unknown 10 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2016.
All research outputs
#13,488,874
of 22,903,988 outputs
Outputs from Annals of Clinical Microbiology and Antimicrobials
#234
of 610 outputs
Outputs of similar age
#207,347
of 415,136 outputs
Outputs of similar age from Annals of Clinical Microbiology and Antimicrobials
#2
of 4 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 610 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 415,136 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.