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Attention Score in Context
| Title |
Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling
|
|---|---|
| Published in |
Nutrition & Metabolism, November 2016
|
| DOI | 10.1186/s12986-016-0147-1 |
| Pubmed ID | |
| Authors |
F. Edland, A. Wergeland, R. Kopperud, K. S. Åsrud, E. A. Hoivik, S. L. Witsø, R. Æsøy, L. Madsen, K. Kristiansen, M. Bakke, S. O. Døskeland, A. K. Jonassen |
| Abstract |
Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the "obesity paradox". This study explores if long-term feeding of an obesogenic high fat diet renders the myocardium less susceptible to ischemic-reperfusion induced injury via Epac-dependent signaling. Wild type (wt), Epac1 (Epac1(-/-)) and Epac2 (Epac2(-/-)) deficient mice were fed a high fat (HFD) or normal chow diet (ND) for 33 ± 1 weeks. Six experimental groups were included: (1) control wt ND (wt ND), (2) control wt HFD (wt HFD), (3) Epac1(-/-) mice on ND (Epac1(-/-)ND), (4) Epac1(-/-) mice on HFD (Epac1(-/-)HFD), (5) Epac2(-/-) mice on ND (Epac2(-/-)ND), and (6) Epac2(-/-) mice on HFD (Epac2(-/-)HFD). Isolated ex vivo mice hearts were perfused in a constant pressure Langendorff mode, and exposed to 30min of global ischemia (GI) and 60min of reperfusion. Endpoints were infarct size and functional recovery. All groups fed a HFD presented with significantly enhanced body weight, visceral fat content and reduced glucose clearance compared to corresponding ND groups. Although the HFD cohorts presented with an overall comparable systemic capability to clear glucose, the Epac1(-/-) HFD group presented with glucose levels slightly above the human diabetes criteria at the end of the intraperitoneal glucose tolerance test (ipGTT). Moreover, the HFD significantly reduced infarct size in both wild type (wt HFD 41.3 ± 5.5% vs. wt ND 58.0 ± 9.8%, p < 0.05) and Epac2(-/-) cohorts (Epac2(-/-)HFD 34.4 ± 7.2% vs. Epac2(-/-)ND 56.5 ± 3.8%, p < 0.05). Interestingly, however, the HFD did not reduce infarct size in Epac1(-/-) deficient mice hearts (Epac1(-/-)HFD 65.1 ± 5.1% vs. Epac1(-/-)ND 56.1 ± 3.5%, ns.). Epac1-dependent signaling is involved in mediating the cardioprotection afforded by long-term feeding of an obesogenic high fat diet in mice hearts. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 19% |
| Student > Master | 3 | 11% |
| Student > Bachelor | 2 | 7% |
| Student > Postgraduate | 2 | 7% |
| Student > Ph. D. Student | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 10 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 30% |
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Nursing and Health Professions | 2 | 7% |
| Unspecified | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 10 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2016.
All research outputs
#15,395,259
of 22,903,988 outputs
Outputs from Nutrition & Metabolism
#673
of 949 outputs
Outputs of similar age
#250,752
of 416,651 outputs
Outputs of similar age from Nutrition & Metabolism
#19
of 25 outputs
Altmetric has tracked 22,903,988 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 949 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,651 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.