Title |
Dynamic cross-regulation of antigen-specific effector and regulatory T cell subpopulations and microglia in brain autoimmunity
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Published in |
BMC Systems Biology, April 2013
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DOI | 10.1186/1752-0509-7-34 |
Pubmed ID | |
Authors |
Sara Martinez-Pasamar, Elena Abad, Beatriz Moreno, Nieves Velez de Mendizabal, Ivan Martinez-Forero, Jordi Garcia-Ojalvo, Pablo Villoslada |
Abstract |
Multiple Sclerosis (MS) is considered a T-cell-mediated autoimmune disease with a prototypical oscillatory behavior, as evidenced by the presence of clinical relapses. Understanding the dynamics of immune cells governing the course of MS, therefore, has many implications for immunotherapy. Here, we used flow cytometry to analyze the time-dependent behavior of antigen-specific effector (T(eff)) and regulatory (T(reg)) T cells and microglia in mice model of MS, Experimental Autoimmune Encephalomyelitis (EAE), and compared the observations with a mathematical cross-regulation model of T-cell dynamics in autoimmune disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 3% |
United Kingdom | 1 | 1% |
Mexico | 1 | 1% |
Unknown | 67 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 18% |
Student > Ph. D. Student | 12 | 17% |
Student > Master | 8 | 11% |
Student > Bachelor | 8 | 11% |
Student > Postgraduate | 5 | 7% |
Other | 16 | 23% |
Unknown | 9 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 28% |
Medicine and Dentistry | 13 | 18% |
Immunology and Microbiology | 5 | 7% |
Neuroscience | 4 | 6% |
Engineering | 4 | 6% |
Other | 17 | 24% |
Unknown | 8 | 11% |