Title |
Chagas' heart disease: gender differences in myocardial damage assessed by cardiovascular magnetic resonance
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Published in |
Critical Reviews in Diagnostic Imaging, November 2016
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DOI | 10.1186/s12968-016-0307-5 |
Pubmed ID | |
Authors |
Antonildes N. Assunção, Michael Jerosch-Herold, Rodrigo L. Melo, Alejandra V. Mauricio, Liliane Rocha, Jorge A. Torreão, Fabio Fernandes, Barbara M. Ianni, Charles Mady, José A. F. Ramires, Roberto Kalil-Filho, Carlos E. Rochitte |
Abstract |
Since a male-related higher cardiovascular morbidity and mortality in patients with Chagas' heart disease has been reported, we aimed to investigate gender differences in myocardial damage assessed by cardiovascular magnetic resonance (CMR). Retrospectively, 62 seropositive Chagas' heart disease patients referred to CMR (1.5 T) and with low probability of having significant coronary artery disease were included in this analysis. Amongst both sexes, there was a strong negative correlation between LV ejection fraction and myocardial fibrosis (male r = 0.64, female r = 0.73, both P < 0.001), with males showing significantly greater myocardial fibrosis (P = 0.002) and lower LV ejection fraction (P < 0.001) than females. After adjustment for potential confounders, gender remained associated with myocardial dysfunction, and 53% of the effect was mediated by myocardial fibrosis (P for mediation = 0.004). Also, the transmural pattern was more prevalent among male patients (23.7 vs. 9.9%, P < 0.001) as well as the myocardial heterogeneity or gray zone (2.2 vs. 1.3 g, P = 0.003). We observed gender-related differences in myocardial damage assessed by CMR in patients with Chagas' heart disease. As myocardial fibrosis and myocardial dysfunction are associated to cardiovascular outcomes, our findings might help to understand the poorer prognosis observed in males in Chagas' disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 24% |
United Kingdom | 2 | 12% |
Brazil | 1 | 6% |
Unknown | 10 | 59% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 12 | 71% |
Science communicators (journalists, bloggers, editors) | 2 | 12% |
Scientists | 2 | 12% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 11% |
Student > Doctoral Student | 5 | 8% |
Student > Bachelor | 5 | 8% |
Researcher | 4 | 6% |
Student > Postgraduate | 4 | 6% |
Other | 14 | 23% |
Unknown | 23 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 37% |
Agricultural and Biological Sciences | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Nursing and Health Professions | 1 | 2% |
Other | 5 | 8% |
Unknown | 25 | 40% |