Title |
Effects of steroid hormones on differentiated glandular epithelial and stromal cells in a three dimensional cell culture model of the canine endometrium
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Published in |
BMC Veterinary Research, April 2013
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DOI | 10.1186/1746-6148-9-86 |
Pubmed ID | |
Authors |
Cordula Bartel, Alexander Tichy, Susanne Schoenkypl, Christine Aurich, Ingrid Walter |
Abstract |
Oestrogens and progesterone have a significant impact on the endometrium during the canine oestrous cycle. Their receptors mediate plasma steroid hormone levels and are expressed in several endometrial cell types. Altered steroid receptor expression patterns are involved in serious uterine diseases; however the mechanisms of hormone action during pathogenesis in these tissues remain unclear. The development of 3D culture systems of canine endometrial cells provides an opportunity for the effects of steroid hormones to be quantitatively assessed in a more in vivo-like setting. The present study aimed to determine the effects of the steroid hormones 17β-estradiol (E) and progesterone (P) on the expression of the oestrogen and progesterone receptors (ER and PR), and on proliferative activity, in a 3D co-culture system of canine uterine origin, comprising differentiated endometrial glands, and stromal cells (SCs). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 20% |
Researcher | 6 | 15% |
Student > Master | 5 | 12% |
Student > Doctoral Student | 4 | 10% |
Student > Bachelor | 3 | 7% |
Other | 6 | 15% |
Unknown | 9 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 24% |
Biochemistry, Genetics and Molecular Biology | 7 | 17% |
Veterinary Science and Veterinary Medicine | 5 | 12% |
Medicine and Dentistry | 5 | 12% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 5% |
Unknown | 11 | 27% |