Title |
The extracellular microscape governs mesenchymal stem cell fate
|
---|---|
Published in |
Journal of Biological Engineering, November 2016
|
DOI | 10.1186/s13036-016-0037-0 |
Pubmed ID | |
Authors |
William J. Hadden, Yu Suk Choi |
Abstract |
Each cell forever interacts with its extracellular matrix (ECM); a stem cell relies on this interaction to guide differentiation. The stiffness, nanotopography, protein composition, stress and strain inherent to any given ECM influences stem cell lineage commitment. This interaction is dynamic, multidimensional and reciprocally evolving through time, and from this concerted exchange the macroscopic tissues that comprise living organisms are formed. Mesenchymal stem cells can give rise to bone, cartilage, tendon and muscle; thus attempts to manipulate their differentiation must heed the physical properties of incredibly complex native microenvironments to realize regenerative goals. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 23% |
Student > Master | 7 | 15% |
Student > Doctoral Student | 5 | 10% |
Student > Bachelor | 5 | 10% |
Researcher | 4 | 8% |
Other | 5 | 10% |
Unknown | 11 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 17% |
Engineering | 7 | 15% |
Agricultural and Biological Sciences | 6 | 13% |
Medicine and Dentistry | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 8 | 17% |
Unknown | 12 | 25% |