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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity
|
|---|---|
| Published in |
Nutrition Journal, December 2016
|
| DOI | 10.1186/s12937-016-0219-0 |
| Pubmed ID | |
| Authors |
Ehsan Parvaresh Rizi, Sonia Baig, Muhammad Shabeer, Yvonne Teo, Shao Feng Mok, Tze Ping Loh, Faidon Magkos, Sam Virtue, Antonio Vidal-Puig, E. Shyong Tai, Chin Meng Khoo, Sue-Anne Toh |
| Abstract |
Obesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein, or carbohydrate on immunometabolic responses. Nine lean insulin sensitive (LIS) men and 9 obese insulin resistant (OIR) men ingested high-carbohydrate (HC), high-fat (HF) or high-protein (HP) mixed meals in random order. We assessed plasma glucose, insulin, and cytokine responses and cytokine gene expression in circulating mononuclear cells (MNC) at fasting and postprandial states (up to 6-h). Expression of NF-κB and TNFα genes were greater; whereas that of TGFβ and IL-6 genes were lower, in the OIR compared to the LIS individuals. The differences were significantly greater after the HC meal, but not after the HP or HF meal. Similar results were obtained for plasma concentrations of TNFα and IL-6. Our findings indicate that a single HC meal has a distinct adverse effect on immunometabolic responses in the OIR individuals. The cumulative effect of such adverse responses to meals rich in carbohydrate may predispose the OIR individuals to a higher risk of cardiovascular disease. |
X Demographics
The data shown below were collected from the profiles of 91 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 16% |
| Spain | 9 | 10% |
| Canada | 4 | 4% |
| United Kingdom | 4 | 4% |
| Australia | 4 | 4% |
| South Africa | 3 | 3% |
| Ireland | 2 | 2% |
| Panama | 1 | 1% |
| Norway | 1 | 1% |
| Other | 5 | 5% |
| Unknown | 43 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 65 | 71% |
| Practitioners (doctors, other healthcare professionals) | 15 | 16% |
| Scientists | 10 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 16% |
| Student > Bachelor | 16 | 16% |
| Researcher | 12 | 12% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Postgraduate | 6 | 6% |
| Other | 12 | 12% |
| Unknown | 28 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 25% |
| Nursing and Health Professions | 11 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Agricultural and Biological Sciences | 7 | 7% |
| Immunology and Microbiology | 5 | 5% |
| Other | 11 | 11% |
| Unknown | 34 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 57. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2022.
All research outputs
#750,841
of 25,635,728 outputs
Outputs from Nutrition Journal
#221
of 1,531 outputs
Outputs of similar age
#15,156
of 418,046 outputs
Outputs of similar age from Nutrition Journal
#2
of 19 outputs
Altmetric has tracked 25,635,728 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,531 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 418,046 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.